Metabolic Peptide

MOTS-C

Size: 10MG

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MOTS-C GREYLINE research vial
$79.982 vials · $39.99 per vial
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For research use only. Not for human or veterinary use.

Product Description

MOTS-C is a 16-residue mitochondria-derived peptide encoded within a short open reading frame in mitochondrial 12S rRNA. Cell and animal studies connect it with metabolic-stress signaling, AMPK-related pathways, nuclear translocation, and exercise-associated physiology, but those findings do not establish clinical efficacy. Human evidence remains early: a newly registered phase 2a study does not yet provide results, and FDA has reviewed substantial characterization and safety uncertainties for compounded MOTS-c.

Certificate of Analysis

Lot-specific analytical results and downloadable documentation

LOT-SPECIFICNO DOCUMENT ON FILE
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Product
MOTS-C
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Compound Information

Technical specifications

Molecular Profile

What is MOTS-C?

Type
Mitochondria-derived research peptide
CAS number
1627580-64-6
Molecular weight
2174.6 g/mol
Amino acids
16-residue peptide
Molecular formula
C101H152N28O22S2
PubChem: MOTS-c (human)
Storage Requirements

Stability Information

Formulation-specific stability unknownKeep sealed and dryProtect from light
Lyophilized / unopenedNo product-specific shelf life supplied; follow a qualified laboratory SOP.
Reconstituted / in solutionNo authoritative hold time supplied; use a validated laboratory protocol.

No FDA-approved MOTS-c drug product or transferable labeled storage standard exists.

Sources & References

Peer-reviewed and authoritative records

Cell Metabolism

Primary research

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

2015·DOI: 10.1016/j.cmet.2015.02.009

Lee C, Zeng J, Drew BG, et al.

View Source

Cell Metabolism

Primary research

The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress

2018·DOI: 10.1016/j.cmet.2018.06.008

Kim KH, Son JM, Benayoun BA, Lee C

View Source

Nature Communications

Primary research

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

2021·DOI: 10.1038/s41467-020-20790-0

Reynolds JC, Lai RW, Woodhead JST, et al.

View Source

ClinicalTrials.gov

Clinical trial registry

MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity (MOTS-MET; NCT07505745)

2026

Hudson Biotech

View Source

U.S. Food and Drug Administration

Regulatory scientific review

MOTS-c: Pharmacy Compounding Advisory Committee Scientific Review

2026

U.S. Food and Drug Administration

View Source

Important Research Notice

Not for human consumption. This product is sold exclusively for laboratory, analytical, and educational research purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

Research information presented on this page is provided for educational reference and should not be interpreted as medical advice or as a product claim.

By purchasing this product, the customer confirms that it will be handled and used only by qualified individuals in accordance with all applicable laws and laboratory procedures.

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